Python-RSA before 4.1 ignores leading '\0' bytes during decryption of ciphertext. This could conceivably have a security-relevant impact, e.g., by helping an attacker to infer that an application uses Python-RSA, or if the length of accepted ciphertext affects application behavior (such as by causing excessive memory allocation).

It was found that python-rsa is vulnerable to Bleichenbacher timing attacks. An attacker can use this flaw via the RSA decryption API to decrypt parts of the cipher text encrypted with RSA.